Annexin A1 (ANXA1): A Systematic Review of Its Role in Inflammation

Inflammation is a body response towards any injury or tissue damage. It involves the accumulation of neutrophils and release inflammatory mediators. ANXA1, 37 kDa glucocorticoid inducible protein plays an important role in resolving inflammation. The unique N-terminal its mimetic peptide exert strong anti-inflammatory actions. This study was conducted to review roles ANXA1 inflammation identify other reported roles. Electronic search done whereby total 3797 articles were located from three databases, namely Ovid MEDLINE, Science Direct, PubMed. Articles on selected based inclusive criteria papers excluded. Bias analysis performed bias risk tool 27 included study. found that able resolve many diseases. Upon treatment with glucocorticoid, induced significant expressions tissues are However, this effect can be reversed by administering anti-annexin antibody. also acts members all formyl receptors (FPR) activates them initiate reaction. mainly causing death through apoptosis. In addition, identified as marker cancer cells which determines survival rates. conclusion, key modulator diseases actively being upon treatment.